McDonald’s Corp’s U.S. restaurants will gradually stop buying chicken raised with antibiotics vital to fighting human infections, the most aggressive step by a major food company to change chicken producers’ practices in the fight against dangerous ‘superbugs.’

The world’s biggest restaurant chain announced on Wednesday that within two years, McDonald’s USA will only buy chickens raised without antibiotics that are important to human medicine. The concern is that the overuse of antibiotics for poultry may diminish their effectiveness in fighting disease in humans. McDonald’s policy will begin at the hatchery, where chicks are sometimes injected with antibiotics while still in the shell.

“We’re listening to our customers,” Marion Gross, senior vice president of McDonald’s North American supply chain, told Reuters. She said the company is working with its domestic chicken suppliers, including Tyson Foods Inc, to make the transition.

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