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Merck AIDS Vaccine Failure May Doom Promising Study
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John Lauerman / Bloomberg | March 24, 2008
A once-promising study of an AIDS vaccine developed by the U.S. will be scaled back and may be scrubbed after the failure of a related Merck & Co. effort.
The vaccine, created by the U.S. National Institutes of Health’s Vaccine Research Center in Bethesda, Maryland, may be studied in about only 2,000 people in the U.S. and Africa, rather than 8,500 as had been planned. An international AIDS research group that has helped bring six vaccines to human testing will say today that it has pulled out of the trial.
Support has declined for clinical studies of existing experimental AIDS vaccines since September, when Merck announced its shot may have made people more vulnerable to infection. AIDS researchers say concern was further heightened this month after a second test of Merck’s product, conducted in South Africa, found more infections among those vaccinated.
“There isn’t a clear understanding of why,” said Wayne Koff, senior vice president for research and development for the International AIDS Vaccine Initiative, based in New York. Koff said in an interview that his group told the NIH last week it wouldn’t participate in the vaccine trial, called PAVE-100.
“I think we have a safety unknown here,” Koff said. His group, which funds and manages AIDS vaccine research, is notifying its affiliated testing sites in Africa that it won’t help enroll participants to carry out the U.S. trial.
Opposition to the Trial
More than 33 million people worldwide are infected with HIV, a lethal germ, spread through sex and infected blood, that causes AIDS. While about two dozen AIDS drugs are approved, lifetime treatment costs for each U.S. patient are estimated at almost $619,000, and doctors say a vaccine is essential to preventing new cases. The failure of the Merck shot will set back HIV vaccine research for years, scientists have said.
The AIDS Healthcare Foundation, the Los Angeles-based provider of care and support for about 65,000 patients in 20 countries, called for a moratorium on HIV vaccine research.
“It’s unfortunate that it took an AIDS vaccine trial that made more people become infected to make people pay attention and stop this runaway train,” said Michael Weinstein, the group’s president, in a telephone interview today. “There’s no validity in the underlying idea that there will be an AIDS vaccine.”
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Before spending more money and time on a human test of the government’s vaccine, researchers should go back to trying to understand the AIDS virus, said Ronald Desrosiers, a Harvard University scientist.
“I am against seeing it go forward,” he said in an e- mail. “I am willing to listen to arguments to the contrary, but have not heard any yet to make me feel otherwise.”
`A Post-Merck World’
David Baltimore, a Nobel Prize winner and leading expert on the AIDS virus, told the American Association for the Advancement of Science meeting in Boston last month that no progress on a vaccine has been made since the disease was discovered 25 years ago.
While AIDS vaccine trials still have merit, for the immediate future, they should be designed to answer questions about how they work, rather than whether they can prevent transmission of the virus, Mitchell Warren, executive director of the New York-based AIDS Vaccine Advocacy Coalition, said in a telephone interview last week.
“We’re living in a post-Merck world and we’re going to have to ask questions in a different way and operate in a different reality,” he said. Merck officials declined to comment on the U.S. study.
Recruitment Challenges
The U.S. vaccine, referred to as the VRC vaccine for the center where it was developed, has at least two features in common with Merck’s. Both aim to arouse immune defenders called T-cells against HIV, and both contain a cold virus called adenovirus-5.
In the Merck study, vaccinated men were at increased risk of HIV if they started the study with a high level of immunity to the cold virus, meaning they previously had been exposed to the virus. Researchers saw the same pattern in early results of an African test of the Merck vaccine, which was also halted last year on safety concerns.
No one with high levels of immunity to adenovirus-5 will be enrolled in the government vaccine trial, called PAVE-100, should it proceed, said Anthony Fauci, director of the U.S. National Institute of Allergy and Infectious Diseases, part of the NIH. That may rule out nine of 10 of potential participants in Africa, where levels of infection with the adenovirus are much higher than in the U.S, Koff said. A requirement that men in the study be circumcised, rare in some African communities, would also complicate recruitment, he said.
“We were convinced that we would have a difficult time enrolling significant numbers of individuals,” Koff said.
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March 24th, 2008 at 5:40 pm
First they have to prove a virus exists that causes AIDS before they can sell a vaccine. See the videos ‘Deconstructing the Myth of AIDS’ and ‘The Otherside of AIDS’ if you still believe there is a virus called HIV that causes AIDS.
March 24th, 2008 at 8:36 pm
There is a device that you can wear on your wrist for a few weeks if you have HIV (not fully developed aids, wont work with this.) This device sends a low (very low) current through your blood and the HIV can not live in it, it will die off in weeks, scientifically curing HIV. People have used it with 100% success and zero side effects. This is our best shot of curing aids so far.
March 24th, 2008 at 8:40 pm
Aids was not a naturally occurring disease. It was developed in a lab and it is a weapon to depopulate the underdeveloped nations.
On Dec. 10, 1974, the U.S. National Security Council under Henry Kissinger completed a classified 200-page study, “National Security Study Memorandum 200: Implications of Worldwide Population Growth for U.S. Security and Overseas Interests.” The study falsely claimed that population growth in the so-called Lesser Developed Countries (LDCs) was a grave threat to U.S. national security. Adopted as official policy in November 1975 by President Gerald Ford, NSSM 200 outlined a covert plan to reduce population growth in those countries through birth control, and also, implicitly, war and famine. Brent Scowcroft, who had by then replaced Kissinger as national security adviser (the same post Scowcroft was to hold in the Bush administration), was put in charge of implementing the plan. CIA Director George Bush was ordered to assist Scowcroft, as were the secretaries of state, treasury, defense, and agriculture.
http://www.larouchepub.com/oth....._food.html
March 24th, 2008 at 11:05 pm
They do all this vaccine stuff cuz it make them tonnes of money
March 24th, 2008 at 11:41 pm
Merck is a sponsor of NPR radio!
March 25th, 2008 at 12:03 am
HIV is bullshit. But the brilliant propaganda surrounding it convinces people they are sick,(see reverse placebo effect), it encourages people to use protection to keep population down. Doses them with drugs that immitate AIDS, thus justifying the epidemic.
HIV was created in a lab, not a science lab, but a pyschological warfare lab. Learn how the testing is done and you media experts will know I’m on to something. The Whole HIV/AIDS industry is run like an Orwellian government. I kid you not.
March 25th, 2008 at 12:59 pm
To all Montrealers. Montreal 9-11 Truth.org .:Change of Meeting Location For Tonight
Since some people have raised concerns about the initial plan to meet-up
right next to the ticket booths in Berri, in front of Verint’s cameras,we have decided to meet instead on the corner of Berri and Sainte-Catherine. The time remains the same at 19h30. The contact person will be Simon (who has a beard and a green and black coat).
BUT
Should some people not get this message on time I , Michael Pengue, will try to meet any others folks who are waiting at the original meeting location (downstairs in metro berri).
Cordially,
Michael and Simon
March 25th, 2008 at 1:27 pm
The cure for AIDS is NOT BEING A DEGENARATE. What a waste of money. The #1 leading cause of death in the world is still sin. But like the NAU, according to junk scientists and the Satanic globalist aristocracy, sin doesn’t exist. It’s just a perception. LOL.
March 25th, 2008 at 2:11 pm
HIV doesn’t cause AIDS. The HIV hypothesis is as fake as man made global warming. Check out http://www.duesberg.com .
HIV is a patsy. By blaming AIDS on HIV the medical establishment gets to make lots of money by endless treatment attempts and the New World Order gets to cover up it’s genocide programs in Africa.
Alex Jones has often said that AIDS is a genetically engineered weapon. That may well be true. However it’s not HIV that’s doing it and it’s not sexually transmitted. It’s probably caused by a combination of different things, but definitely drug abuse, reverse placebo effect, AIDS medication and whatever nasty stuff the New World Order puts in the 3rd world vaccinations.
March 25th, 2008 at 6:15 pm
CURE FOR AIDS..CANCER..OTHER DISEASE IS ..BLOOD ELECTROFICUTION
March 25th, 2008 at 6:17 pm
metallic coloidal suppliments also help charge the bloodstream in order to repel foreign elements.