October 18, 2012
Triple-negative breast cancer (TNBC) is one of the most aggressive and deadly forms of breast cancer. It is harder to detect, grows the fastest, spreads earlier to other parts of the body and recurs more often. What’s more, the arsenal of drugs and chemicals currently used by mainstream medicine to treat TNBC are so toxic that patients often can’t tolerate the treatment — and chemotherapy is often ineffective anyway.
But at the 2012 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition underway in Chicago, scientists have just announced what they say is an “effective treatment” for TNBC. The key to this discovery? Compounds derived from diindolylmethane (DIM), a natural-occurring chemical commonly found in various types of cruciferous vegetables, especially Brussels sprouts and broccoli.
“We are confident that the compounds we are currently working with are an effective treatment for triple-negative breast cancer. These compounds are safer for the patient than current treatments available,” said Mandip Sachdeva, Ph.D., who made the breakthrough along with his Florida A&M University colleagues Chandraiah Godugu, Ph.D. and Stephen Safe, Ph.D., from Texas A&M University.