The Facebook founder said atrocities in Belgium, Pakistan and Turkey were all designed to sow seeds of hatred between different communities.
He said: “Each of these attacks were carried out with a goal to spread fear and distrust, and turn members of a community against each other.”
The “only sustainable way to fight back” against the sickening attacks is to “create a world” where everyone “feels cared for and loved”, he added.
The militants said they deliberately targeted the Christian community in the attack, launched on the holiest day of the Christian calendar.
It came after Islamic State militants killed dozens more by attacking Brussels and Ankara, the Belgian and Turkish capitals respectively.